The research programme consists of 10 individual PhD projects relating to "Host-pathogen interactions" that are performed by the 10 EIMID ITN fellows. The urgency of deep studies on this topic is evident not only in the Third World, where infectious diseases exact a heavy toll in particular on very young children, but also in industrialised countries, where new emergencies and re-emerging old diseases pose actual threats to the population health. Thus, as main goal EIMID aims at developing innovative approaches for the control of bacterial infections of great relevance for both the industrialised and developing world, ideally by generating new vaccines or novel strategies to antagonise infectious mechanisms. The research projects are designed in order to be collaborative with at least one of the other EIMID institutions and will be carried out in parallel in the six EIMID institutes in an integrated fashion, allowing the students to exchange technical experience by frequent visits among the participant laboratories. The individual PhD projects are listed below:

1. Investigation of metabolic antigens expressed by Non-typeable Haemophilus influenzae during biofilm formation for
     vaccine development

2. Investigation of the biological role of surface proteins in Staphylococcus Aureus pathogenesis
3. Replication dynamics of Streptococcus pyogenes
4. Regulation of Shigella virulence
5. Deciphering the regulatory mechanisms of transcription of antibacterial factors of the gut epithelium
6. A new secreted protein involved in the virulence of the bacterial pathogen Listeria monocytogenes
7. The role of immune cells in pneumococcal infections
8. Comparative genomics and functional characterization of pneumococci and interactions with host cells and innate
     immune responses

9. The human B cell response to factor H binding protein of Neisseria meningitidis
10. Identification and analysis of host cell functions essential for viral replication